Artificial Intelligence (AI) is rapidly transforming healthcare, notably in cognitive decline research and personalized medicine. Leveraging advanced machine learning, AI facilitates early detection of conditions like Alzheimer’s, personalizes treatments based on genetic and lifestyle factors, and accelerates drug discovery. Integrating genomic analysis, real-time patient monitoring, and precision healthcare strategies, AI promises significant improvements in patient outcomes. However, addressing ethical considerations such as data privacy, algorithmic bias, and transparency remains crucial. As we move towards AAN 2025, embracing AI responsibly will profoundly shape healthcare’s future, enhancing both diagnostics and personalized treatment pathways.